Setaria digitata adult 14- to 20-kDa antigens induce differential Th1/Th2 cytokine responses in the lymphocytes of endemic normals and asymptomatic microfilariae carriers in bancroftian filariasis.
Identifieur interne : 00B064 ( Main/Exploration ); précédent : 00B063; suivant : 00B065Setaria digitata adult 14- to 20-kDa antigens induce differential Th1/Th2 cytokine responses in the lymphocytes of endemic normals and asymptomatic microfilariae carriers in bancroftian filariasis.
Auteurs : S K Dalai [Inde] ; D. Das ; S K KarSource :
- Journal of clinical immunology [ 0271-9142 ] ; 1998.
Descripteurs français
- KwdFr :
- Activation des lymphocytes (immunologie), Adolescent, Adulte, Adulte d'âge moyen, Animaux, Antigènes d'helminthe (immunologie), Antigènes d'helminthe (sang), Bovins, Cytokines (biosynthèse), Cytokines (immunologie), Cytokines (sang), Femelle, Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Filariose lymphatique (sang), Humains, Immunoglobuline G (immunologie), Isotypes des immunoglobulines (immunologie), Lymphocytes auxiliaires Th1 (immunologie), Lymphocytes auxiliaires Th1 (métabolisme), Lymphocytes auxiliaires Th2 (immunologie), Lymphocytes auxiliaires Th2 (métabolisme), Microfilaria, Mâle, Porteur sain, Setaria (nématode) (immunologie), Épitopes (immunologie).
- MESH :
- biosynthèse : Cytokines.
- immunologie : Activation des lymphocytes, Antigènes d'helminthe, Cytokines, Filariose lymphatique, Immunoglobuline G, Isotypes des immunoglobulines, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2, Setaria (nématode), Épitopes.
- métabolisme : Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2.
- parasitologie : Filariose lymphatique.
- sang : Antigènes d'helminthe, Cytokines, Filariose lymphatique.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Bovins, Femelle, Humains, Microfilaria, Mâle, Porteur sain.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Antigens, Helminth (blood), Antigens, Helminth (immunology), Carrier State, Cattle, Cytokines (biosynthesis), Cytokines (blood), Cytokines (immunology), Elephantiasis, Filarial (blood), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Epitopes (immunology), Female, Humans, Immunoglobulin G (immunology), Immunoglobulin Isotypes (immunology), Lymphocyte Activation (immunology), Male, Microfilariae, Middle Aged, Setaria Nematode (immunology), Th1 Cells (immunology), Th1 Cells (metabolism), Th2 Cells (immunology), Th2 Cells (metabolism).
- MESH :
- chemical , biosynthesis : Cytokines.
- chemical , blood : Antigens, Helminth, Cytokines.
- chemical , immunology : Antigens, Helminth, Cytokines, Epitopes, Immunoglobulin G, Immunoglobulin Isotypes.
- blood : Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial, Lymphocyte Activation, Setaria Nematode, Th1 Cells, Th2 Cells.
- metabolism : Th1 Cells, Th2 Cells.
- parasitology : Elephantiasis, Filarial.
- Adolescent, Adult, Animals, Carrier State, Cattle, Female, Humans, Male, Microfilariae, Middle Aged.
Abstract
High titers of parasite antigen-specific IgG4 antibodies have been found to be circulating in the peripheral blood of chronic patients, asymptomatic microfilariae carriers, and endemic normals in bancroftian filariasis. But in contrast to this, the titers of antigen-specific IgG1, IgG2, and IgG3 isotype antibodies are much lower. Using soluble antigens of adult Setaria digitata, a cattle parasite which shows strong antigenic reactivity with filaria sera, we have identified, by immunoblot, 14- to 20-kDa antigens which are recognized only by the IgG4 isotype antibodies present in the sera of asymptomatic microfilariae carriers. These 14- to 20-kDa antigens, after fractionation by SDS-PAGE and transfer to nitrocellulose paper, when solubilized and tested in vitro, induced secretion of a higher quantity of IFN-gamma and a lower quantity of IL-4, IL-5, and IL-10 (differential Th1 and Th2 response) in the lymphocytes of endemic normals in comparison to what they induced in the lymphocytes of asymptomatic microfilariae carriers.
PubMed: 9533655
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 004F17
- to stream PubMed, to step Curation: 004F17
- to stream PubMed, to step Checkpoint: 004F17
- to stream Ncbi, to step Merge: 00BB50
- to stream Ncbi, to step Curation: 00BB50
- to stream Ncbi, to step Checkpoint: 00BB50
- to stream Main, to step Merge: 00B720
- to stream Main, to step Curation: 00B064
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Setaria digitata adult 14- to 20-kDa antigens induce differential Th1/Th2 cytokine responses in the lymphocytes of endemic normals and asymptomatic microfilariae carriers in bancroftian filariasis.</title>
<author><name sortKey="Dalai, S K" sort="Dalai, S K" uniqKey="Dalai S" first="S K" last="Dalai">S K Dalai</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Biotechnology, Jawaharlal Nehru University, New Delhi, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Centre for Biotechnology, Jawaharlal Nehru University, New Delhi</wicri:regionArea>
<wicri:noRegion>New Delhi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Das, D" sort="Das, D" uniqKey="Das D" first="D" last="Das">D. Das</name>
</author>
<author><name sortKey="Kar, S K" sort="Kar, S K" uniqKey="Kar S" first="S K" last="Kar">S K Kar</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1998">1998</date>
<idno type="RBID">pubmed:9533655</idno>
<idno type="pmid">9533655</idno>
<idno type="wicri:Area/PubMed/Corpus">004F17</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004F17</idno>
<idno type="wicri:Area/PubMed/Curation">004F17</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004F17</idno>
<idno type="wicri:Area/PubMed/Checkpoint">004F17</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">004F17</idno>
<idno type="wicri:Area/Ncbi/Merge">00BB50</idno>
<idno type="wicri:Area/Ncbi/Curation">00BB50</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">00BB50</idno>
<idno type="wicri:doubleKey">0271-9142:1998:Dalai S:setaria:digitata:adult</idno>
<idno type="wicri:Area/Main/Merge">00B720</idno>
<idno type="wicri:Area/Main/Curation">00B064</idno>
<idno type="wicri:Area/Main/Exploration">00B064</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Setaria digitata adult 14- to 20-kDa antigens induce differential Th1/Th2 cytokine responses in the lymphocytes of endemic normals and asymptomatic microfilariae carriers in bancroftian filariasis.</title>
<author><name sortKey="Dalai, S K" sort="Dalai, S K" uniqKey="Dalai S" first="S K" last="Dalai">S K Dalai</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Biotechnology, Jawaharlal Nehru University, New Delhi, India.</nlm:affiliation>
<country xml:lang="fr">Inde</country>
<wicri:regionArea>Centre for Biotechnology, Jawaharlal Nehru University, New Delhi</wicri:regionArea>
<wicri:noRegion>New Delhi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Das, D" sort="Das, D" uniqKey="Das D" first="D" last="Das">D. Das</name>
</author>
<author><name sortKey="Kar, S K" sort="Kar, S K" uniqKey="Kar S" first="S K" last="Kar">S K Kar</name>
</author>
</analytic>
<series><title level="j">Journal of clinical immunology</title>
<idno type="ISSN">0271-9142</idno>
<imprint><date when="1998" type="published">1998</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Animals</term>
<term>Antigens, Helminth (blood)</term>
<term>Antigens, Helminth (immunology)</term>
<term>Carrier State</term>
<term>Cattle</term>
<term>Cytokines (biosynthesis)</term>
<term>Cytokines (blood)</term>
<term>Cytokines (immunology)</term>
<term>Elephantiasis, Filarial (blood)</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Elephantiasis, Filarial (parasitology)</term>
<term>Epitopes (immunology)</term>
<term>Female</term>
<term>Humans</term>
<term>Immunoglobulin G (immunology)</term>
<term>Immunoglobulin Isotypes (immunology)</term>
<term>Lymphocyte Activation (immunology)</term>
<term>Male</term>
<term>Microfilariae</term>
<term>Middle Aged</term>
<term>Setaria Nematode (immunology)</term>
<term>Th1 Cells (immunology)</term>
<term>Th1 Cells (metabolism)</term>
<term>Th2 Cells (immunology)</term>
<term>Th2 Cells (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes (immunologie)</term>
<term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Antigènes d'helminthe (immunologie)</term>
<term>Antigènes d'helminthe (sang)</term>
<term>Bovins</term>
<term>Cytokines (biosynthèse)</term>
<term>Cytokines (immunologie)</term>
<term>Cytokines (sang)</term>
<term>Femelle</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Filariose lymphatique (parasitologie)</term>
<term>Filariose lymphatique (sang)</term>
<term>Humains</term>
<term>Immunoglobuline G (immunologie)</term>
<term>Isotypes des immunoglobulines (immunologie)</term>
<term>Lymphocytes auxiliaires Th1 (immunologie)</term>
<term>Lymphocytes auxiliaires Th1 (métabolisme)</term>
<term>Lymphocytes auxiliaires Th2 (immunologie)</term>
<term>Lymphocytes auxiliaires Th2 (métabolisme)</term>
<term>Microfilaria</term>
<term>Mâle</term>
<term>Porteur sain</term>
<term>Setaria (nématode) (immunologie)</term>
<term>Épitopes (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antigens, Helminth</term>
<term>Cytokines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term>
<term>Cytokines</term>
<term>Epitopes</term>
<term>Immunoglobulin G</term>
<term>Immunoglobulin Isotypes</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Antigènes d'helminthe</term>
<term>Cytokines</term>
<term>Filariose lymphatique</term>
<term>Immunoglobuline G</term>
<term>Isotypes des immunoglobulines</term>
<term>Lymphocytes auxiliaires Th1</term>
<term>Lymphocytes auxiliaires Th2</term>
<term>Setaria (nématode)</term>
<term>Épitopes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term>
<term>Lymphocyte Activation</term>
<term>Setaria Nematode</term>
<term>Th1 Cells</term>
<term>Th2 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Th1 Cells</term>
<term>Th2 Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphocytes auxiliaires Th1</term>
<term>Lymphocytes auxiliaires Th2</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antigènes d'helminthe</term>
<term>Cytokines</term>
<term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Animals</term>
<term>Carrier State</term>
<term>Cattle</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Microfilariae</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Bovins</term>
<term>Femelle</term>
<term>Humains</term>
<term>Microfilaria</term>
<term>Mâle</term>
<term>Porteur sain</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">High titers of parasite antigen-specific IgG4 antibodies have been found to be circulating in the peripheral blood of chronic patients, asymptomatic microfilariae carriers, and endemic normals in bancroftian filariasis. But in contrast to this, the titers of antigen-specific IgG1, IgG2, and IgG3 isotype antibodies are much lower. Using soluble antigens of adult Setaria digitata, a cattle parasite which shows strong antigenic reactivity with filaria sera, we have identified, by immunoblot, 14- to 20-kDa antigens which are recognized only by the IgG4 isotype antibodies present in the sera of asymptomatic microfilariae carriers. These 14- to 20-kDa antigens, after fractionation by SDS-PAGE and transfer to nitrocellulose paper, when solubilized and tested in vitro, induced secretion of a higher quantity of IFN-gamma and a lower quantity of IL-4, IL-5, and IL-10 (differential Th1 and Th2 response) in the lymphocytes of endemic normals in comparison to what they induced in the lymphocytes of asymptomatic microfilariae carriers.</div>
</front>
</TEI>
<affiliations><list><country><li>Inde</li>
</country>
</list>
<tree><noCountry><name sortKey="Das, D" sort="Das, D" uniqKey="Das D" first="D" last="Das">D. Das</name>
<name sortKey="Kar, S K" sort="Kar, S K" uniqKey="Kar S" first="S K" last="Kar">S K Kar</name>
</noCountry>
<country name="Inde"><noRegion><name sortKey="Dalai, S K" sort="Dalai, S K" uniqKey="Dalai S" first="S K" last="Dalai">S K Dalai</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00B064 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00B064 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:9533655 |texte= Setaria digitata adult 14- to 20-kDa antigens induce differential Th1/Th2 cytokine responses in the lymphocytes of endemic normals and asymptomatic microfilariae carriers in bancroftian filariasis. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:9533655" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |